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By Takashi Isobe (auth.), Takashi Isobe, Shukuro Araki, Fumiya Uchino, Shozo Kito, Eiro Tsubura (eds.)

ISBN-10: 1475702981

ISBN-13: 9781475702989

ISBN-10: 1475703007

ISBN-13: 9781475703009

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Previous studies(3,4) in our laboratories have shown that prolonged immunization of rabbits with heat-killed Escherichia coli 0:14 containing a common enterobacterial antigen suspended in Freund's incomplete adjuvant induced chronic polyarthritis resembling RA. coli 0:14 were examined for amyloid deposition to determine the relationship between occurrence of amyloidosis and arthritis. Furthermore, strain differences in the animals' susceptibility to the developrnent of joint lesions and amyloidosis were examined.

It seems that pathogenetic substance in liver has such character as: (1) easily degraded by freezing and thawing, or lympholization; (2) stable at 4°C for 24 hr; (3) digested by trypsin. It has a molecular weight of about 150,000 - 160,000 daltons and 30,000 40,000 daltons. In our transfer study, it was indicated that nylon wool adherent T cells with Ly 123+ phenotype of donor mice play an important role in the induction of systemic amyloidosis, and that these T cells may work as helper or amplifier cells.

Figure 2 illustrates the numbers of papers, pages, and mean numbers of pages per paper of amyloid publications relative to the other non-amyloid papers from the selection of journals. It is clear that, quite apart from their intrinsic intellectual value, the sheer mimher of papers and pages devoted to amyloidosis tend to the positions of dominance compared to these other already very well-known journals. 12 NON-AMYLOID PUBLICATIONS 800 2400 8 700 600 2200 2 8 2000 3 2 13 400 1600 1400 200 " Mo Md 64 9 7 311 51 12 1200 10 800 100 8 PAPERS Figure 2.

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Amyloid and Amyloidosis by Takashi Isobe (auth.), Takashi Isobe, Shukuro Araki, Fumiya Uchino, Shozo Kito, Eiro Tsubura (eds.)

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